Karabiner allows to customize almost any aspect of the keymap on Mac OS X in a convenient way:
Karabiner – A powerful and stable keyboard customizer for OS X. (formerly known as KeyRemap4MacBook)
For example, you can make the “Home” and “End” keys behave like on a PC. Regarding these two keys, I find the PC style behaviour more intuitive, e.g. using shift-home and shift-end to select text, rather than using the tricky three-finger-combinations shift-cmd-left_cursor and shift-cmd-right_cursor in Mac OS X.
Here’s how to configure this in Karabiner:
Further, I decided to lower the “Key Repeat Delay Until Repeat” to 100 ms and the “Key Repeat” to 23 ms for quicker navigation and repetitive typing.
Of course, there are many other useful tweaks to explore.